MyBioSource.com's Mouse Anti-SMAD3 Antibody is a Mouse monoclonal antibody. The Mouse Anti-SMAD3 Antibody was generated using SMAD3 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, and Immunofluorescence.
Description
Smad proteins, the mammalian homologs of the Drosophila mothers against dpp (Mad) have been implicated as downstream effectors of TGFbeta/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MadH6) are effectors of BMP-2 and BMP-4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFbeta and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFbeta signaling by interfering with TGFbeta-mediated phosphorylation of other Smad family members